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Propofol Half Life. In the postoperative period, the advantage of propofol antiemetic is its rapid onset of action and the absence of serious side effects. Equation · t 1/2 = τ x loge2 · τ = 1/k · cl = k x v d · hence t 1/2 = v d /cl x log e 2.
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13,14 propofol should not be used (or used only after careful consideration) in these cases. Propofol is distributed rapidly and induces sedation within 30 to 60 seconds. Propofol has zero oral bioavailability;
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Equation · t 1/2 = τ x loge2 · τ = 1/k · cl = k x v d · hence t 1/2 = v d /cl x log e 2. 13,14 propofol should not be used (or used only after careful consideration) in these cases. Cardiovascular depression is especially pronounced if propofol is given as a large, rapid bolus,. Propofol is a peripheral vasodilator and myocardial depressant and may cause significant cardiovascular depression in patients that are volume depleted or cardiovascularly compromised.